Open Conference Systems, 50th Scientific meeting of the Italian Statistical Society

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Recurrence dynamics of cancer according to the dormancy paradigm
Elia Biganzoli

Last modified: 2018-06-01


In cancer follow-up, in addition to the evaluation of survival probabilities, there is a fundamental need of assessing recurrence dynamics for optimal disease management. In breast cancer, although the time-dependent effect of the oestrogen receptor (ER) status of the tumour has already been described, so far no factor has proven to disentangle the multi-peak behaviour observed for metastatic recurrences. We proposed frailty models in the tumor dormancy framework, in order to account for possible unobservable dependence mechanisms in cancer studies where a non-negligible proportion of cancer patients relapses years or decades after surgical removal of the primary tumor.

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