This work was included in the study of the degenerative complications of diabetes in the Moroccan diabetic in terms of descriptive and analytical epidemiology.We showed that among 732 patients (366 cases with complication (s) and 366 controls) eligible, 41.2% had retinopathy and 28.4 % had diabetic neuropathy, while 26.2% had cardiovascular complications. In the multivariate analysis, a higher risk of degenerative complications was observed among women with low economic status (OR, adj = 11.36, 95% CI 5.59 to 23.25), women having forgotten the their treatment (Adj. OR = 3.42, 95% CI 1.29-9.09), urban women (adj. OR = 3.97, 95% CI 0.04 - 0.17), Women with a very high level of stress (adj. OR 2.94, 95% CI 1.00 to 8.63), and overweight women (adj. OR = 2.50, 95% CI 1.12 to 5.53 ). However, for men, in the unadjusted analysis, low socio-economic and occupational inactivity were increased the risk of degenerative complication. Overweight men [5.96 (95% CI: 1.61-22.10)], with dyslipidemia [3.09 (95% CI: 1.51-6.33)] and patients treated with a general practitioner [4.57 (95% CI: 1.24 to 16.82)] had a higher risk of degenerative complications. These results are useful for any prevention program, particularly for the early detection of degenerative complications.